Peptollion™
The Blueprint for a Dual-Layer Biologic Future
Developed by Panacea Bio Chem, Peptollion™ represents a new echelon in regenerative biotechnology: a biologically stratified therapeutic that fuses multi-layered peptide synergy with transcriptomic control—within a single vacuum-sealed format.
What Is Peptollion™?
Peptollion™ is a unified biologic platform designed to deliver both tissue regeneration and gene expression modulation in one injectable construct. It combines two technologies:
- Peptourbillon™ – a vertically layered peptide architecture using freeze-stratified sequences
- Oligonucleotide payload – antisense or miRNA-modulating sequences for post-transcriptional regulation
This fusion enables in vivo molecular cooperation between structural repair signals and functional genomic regulators.
The Peptourbillon™ Layer
Engineered Peptide Stratification
The Peptourbillon™ forms the foundational stratum of the Peptollion™ system. Peptides are frozen and layered sequentially before lyophilization. Each layer is constructed at or near its individual eutectic point, preventing molecular degradation or inter-peptide interaction.
All peptides retain native conformation and therapeutic function during storage and reconstitution.
Included peptides may include:
- BPC-157 – Angiogenic, cytoprotective
- TB-500 – Actin-regulation, mobility restoration
- GHK-Cu – ECM remodeling, collagen synthesis, copper shuttling
- Epithalon – Telomerase activation, pineal reprogramming
The Oligonucleotide Layer
Precision Modulation of Gene Expression
Sitting above the Peptourbillon™ strata is a functionally isolated layer of lyophilized, chemically-stabilized oligonucleotides designed to transiently modulate critical gene circuits without altering DNA.
Oligo targets include:
- TGF-β1, CTGF – Anti-fibrotic action
- p16INK4a, miR-34a – Senescence and SASP suppression
- TERT, TRF2 – Telomere length support
- mTOR, SIRT1 – Metabolic and autophagy rebalancing
- p53, p21 – Conditional tumor suppressor reactivation
All oligonucleotides are layered using thermally compatible eutectic freezing and never exposed to thawing post-stratification.
Lyoprester™: The Modus Operandi of Vacuum Integrity
Lyoprester™ is Panacea Bio Chem’s proprietary stratified freeze-drying method. It is not a formulation—it’s a precision-operating protocol for vacuum-sealed storage and reconstitution of layered biologics inside our Panacea Cartridges.
Core functionalities include:
- Sequential freezing of peptides and oligos by eutectic profiling
- Deep vacuum sealing to eliminate oxygen, moisture, and microbial risk
- Instant, air-free reconstitution within the cartridge—no mixing, no external handling
The Lyoprester™ process ensures long-term stability without excipients, cryoprotectants, or preservatives.
The Scientific Purpose of Peptollion™
Peptollion™ is engineered for non-integrative biological control—modulating gene expression and regenerating tissue without entering the genome. This offers a novel path for:
- Studying cellular rejuvenation and aging reversal
- Reversing fibrotic signaling in tissue-specific models
- Promoting non-viral transcriptomic redirection
- Exploring modular combinatorial biology with a single sterile platform
Peptollion™ Pipeline Constructs
- Peptollion-1™ – Anti-fibrotic + regenerative (lung, liver, myocardium)
- Peptollion-2™ – Senescence suppression + telomerase restoration
- Peptollion-3™ – Hormonal modulation + epigenetic telomere support
All constructs follow a dual-pathway rationale: repair the structure, then reprogram the signal.
Research Use Statement
Peptollion™ is not intended for clinical or human use. These systems are built for high-level research in the fields of regenerative biology, molecular reprogramming, and advanced biologic preservation.
Closing Statement
Peptourbillon™ builds. Oligonucleotides instruct. Lyoprester™ preserves.
Peptollion™ is not a therapy—it’s a platform. A multidimensional construct where biological form meets genetic logic.
This is peptollionic science—crafted for those building what comes next in cellular medicine.